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Ipsilateral right testicular metastasis from renal cell carcinoma in a responder patient to interleukine‐2 treatment
Author(s) -
Camerini Andrea,
Tartarelli Gianna,
Martini Leonardo,
Donati Sara,
Puccinelli Paolo,
Amoroso Domenico
Publication year - 2007
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2007.01674.x
Subject(s) - medicine , orchiectomy , testicle , immunotherapy , metastasis , renal cell carcinoma , lung , carcinoma , lymph , urology , pathology , cancer
We present a case of metastatic spreading to the testicle in a 46‐year‐old patient with renal cell carcinoma, ‘clear‐cell’ type, during interleukin‐2 combined subcutaneous plus aerosol treatment. Testicular metastasis occurred while the patient showed a response to the treatment with disappearance of lung lesions and reduction of lymph‐nodes lesions. After orchiectomy with spermatic cord resection and disease re‐evaluation confirming the previous response, the patient re‐started immunotherapy. The contrast between systemic disease response to treatment and disease testicular progression might be explained by a relative insensitivity of the testicle to interleukin‐2 immunotherapy as a result of a possible establishment of an immunosuppressive microenvironment. We believe that the rarity of this metastatic site and the intriguing possible mechanisms at its base, makes an interesting case for clinicians.