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Monotypic epithelioid angiomyolipoma of the kidney: A case report
Author(s) -
MORIOKA MASAAKI,
KINUGAWA KEIGO,
FUNABIKI SADAMI,
MATSUDA TADAKAZU,
FURUKAWA YOJI,
WANI YOJI
Publication year - 2006
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2006.01520.x
Subject(s) - medicine , tuberous sclerosis , pathology , epithelioid cell , angiomyolipoma , eosinophilic , kidney , pathological , perivascular epithelioid cell , hmb 45 , abdominal mass , immunohistochemistry
A case of monotypic variant of epithelioid angiomyolipoma (AML) observed in a 62‐year old woman is reported. The patient complained of abdominal fullness caused by a huge left renal mass without evidence of tuberous sclerosis complex. Imaging studies showed a left renal mass with an area showing hemorrhage and necrosis. The left renal mass, spleen and pancreatic tail were removed en bloc transabdominally. The resected tumor weighed 1200 g and showed focal necrosis and hemorrhage. Microscopically, the tumor was composed exclusively of atypical polygonal cells with copious eosinophilic cytoplasm, pleomorphic nuclei and prominent nucleoli. Tumor cells were considered to derive from perivascular epithelioid cells, and exhibited strong positive staining for HMB‐45 and c‐KIT, but were negative for epithelial, smooth muscle, and neural markers. As this tumor had none of the typical elements of classic AML, the final pathological diagnosis was monotypic epithelioid AML.