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Advanced prostate cancer with extremely low prostate‐specific antigen value at diagnosis: An example of high dose hook effect
Author(s) -
AKAMATSU SHUSUKE,
TSUKAZAKI HIDEKI,
INOUE KOUJI,
NISHIO YASUNORI
Publication year - 2006
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2006.01467.x
Subject(s) - medicine , prostate cancer , prostate specific antigen , urology , prostate , rectal examination , biopsy , cancer , radiology
A 67‐year‐old man presented with a lower abdominal mass. Radiographic examination revealed a huge mass filling the entire pelvis. Although prostate‐specific antigen (PSA) was 1.4 ng/ml, percutaneous needle biopsy revealed adenocarcinoma compatible with prostate cancer, which stained positive for PSA. Hormone therapy was initiated and 1 month later his PSA was as high as 2713 ng/ml, although the mass had decreased in size. High dose hook effect was suspected and hormone therapy was continued. PSA is presently under control and below 0.1 ng/ml. When prostate cancer with very high PSA is suspected and the PSA value is unexpectedly low hook effect should be considered and PSA should be re‐analyzed.