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Possible correlation between polymorphism in the tumor necrosis factor‐beta gene and the clinicopathological features of bladder cancer in Japanese patients
Author(s) -
OMURA NORIO,
TOKIZANE TAKASHI,
NAKAYAMA MASASHI,
INOUE HITOSHI,
NISHIMURA KAZUO,
MURAMATSU MASAAKI,
OKUYAMA AKIHIKO
Publication year - 2006
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2006.01450.x
Subject(s) - bladder cancer , genotype , medicine , allele , tumor necrosis factor alpha , restriction fragment length polymorphism , gene polymorphism , allele frequency , gene , gastroenterology , intron , cancer , pathology , oncology , cancer research , biology , genetics
Objectives: In a variety of cancers, several polymorphisms of the tumor necrosis factor (TNF) genes have been reported to result in different clinical outcomes. We investigated whether a polymorphism of the TNF gene is associated with a susceptibility to bladder cancer and its disease status. Methods: Polymorphisms in the TNF‐α gene promoter (−308 bp) and the Nco I site in the first intron of the TNF‐β gene were analyzed in 141 Japanese patients with bladder cancer and 173 Japanese controls by polymerase chain reaction‐restriction fragment length polymorphism. The correlations between the polymorphisms of the TNF genes and the clinicopathological features were analyzed. Results: The number of cases and controls with TNF‐α2 was too small to be assessable. In contrast, the TNF‐β1/2 genotype at the Nco I site in the first intron conferred a 1.71‐fold increased risk of bladder cancer compared to the TNF‐β2/2 genotype. In the bladder cancer group, patients with the TNF‐β1 allele had a significantly higher risk for a high‐grade tumor (grade 3) or carcinoma in situ (CIS) than those without the TNF‐β1 allele. Moreover, in the superficial bladder cancers, patients with the TNF‐β1 allele showed a significantly higher intravesical recurrence rate than those without the TNF‐β1 allele. Conclusion: This polymorphism in the TNF‐β gene appears to be associated with tumor occurrence and disease status, such as the tumor grade and the presence of CIS. Further study with an increased sample size is warranted.