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11 C‐choline positron emission tomography in bladder cancer: Report of four cases
Author(s) -
YOSHIDA SOICHIRO,
NAKAGOMI KAZUAKI,
GOTO SHUICHI,
FUTATSUBASHI MASAMI,
TORIZUKA TATSUO
Publication year - 2006
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2006.01416.x
Subject(s) - medicine , positron emission tomography , urinary bladder , choline , urinary bladder cancer , bladder cancer , metastasis , urinary system , bone metastasis , scintigraphy , pathology , nuclear medicine , cancer , radiology , urology
Little work has been done with positive emission tomography (PET) in bladder tumors because high urinary excretion of 18 F‐FDG makes visualization of the bladder tumor difficult. 11 C‐choline has recently been reported as a new tracer which lacks urinary radioactivity. We report the result of 11 C‐choline PET in four patients with invasive bladder tumors. In one case, 11 C‐choline PET could detect bladder tumor effectively without urinary activity and bone metastasis despite negative bone scintigraphy. On the other hand, an intense accumulation of the tracer in the bladder hampered the interpretation on PET scanning in three patients. The mechanisms of the 11 C‐choline accumulation in the bladder were reported to be due to inflammatory and proliferative changes in the mucosa of the bladder from previous catheterization or other factors. Further study is necessary to prove the value of 11 C‐choline PET for detecting primary bladder cancer and bone metastasis.