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Neurologic toxicity associated with interferon α therapy for renal cell carcinoma
Author(s) -
WADA YOSHIHIRO,
KUWAHARA TOMOHIRO,
UYAMA EIICHIRO,
NAKANISHI JURO,
TAKAHASHI WATARU,
HONDA JIRO,
KIKUKAWA HIROAKI,
JINNOUCHI YOSHITERU,
UEDA SHOICHI
Publication year - 2006
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2006.01410.x
Subject(s) - medicine , discontinuation , renal cell carcinoma , toxicity , magnetic resonance imaging , lung , interferon , gastroenterology , radiology , pathology , oncology , immunology
A 67‐year‐old man received interferon α (IFN α) therapy for lung metastases of renal cell carcinoma (RCC). Multiple pulmonary metastases disappeared completely. However, neurological toxicity was detected by magnetic resonance imaging (MRI) as abnormal brain lesions. After discontinuation of IFN α therapy, his neurological symptoms and abnormal lesions on MRI disappeared completely. Complete remission of RCC has continued, and results of neurological study have remained normal for 5 years after discontinuation of IFN α therapy.