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Renal transplant patient with polyoma virus bladder infection and subsequent polyoma virus nephropathy
Author(s) -
WEINREB DAVID B,
DESMAN GARRETT T,
BURSTEIN DAVID E,
DIKMAN STEVEN H,
JOHNSON EDWARD M
Publication year - 2006
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2006.01337.x
Subject(s) - medicine , dysuria , bk virus , virus , nephropathy , biopsy , urinary system , renal biopsy , differential diagnosis , kidney , kidney transplantation , pathology , urology , immunology , diabetes mellitus , endocrinology
Polyoma virus nephropathy (PVN) is a significant cause of renal allograft dysfunction in transplant patients. A 58‐year‐old male received a cadaveric renal transplant and 12 weeks later presented with fever, diarrhea, and dysuria. He was diagnosed with a polyoma virus infection of the bladder by a transurethral bladder biopsy. One year post‐transplant, he presented with renal allograft dysfunction and was diagnosed by biopsy with PVN of the non‐native kidney. The diagnosis of a polyoma virus infection was confirmed by immunoreactivity to the polyoma T‐antigen. We suggest that polyoma virus infection of the bladder be included in the differential diagnosis of urinary dysfunction in post‐transplant patients, as such infections might be an under‐recognized comorbidity in individuals with PVN.