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Embryonal carcinoma producing DU‐PAN‐2 with burned‐out phenomenon in the testis
Author(s) -
FUJITA KAZUHIKO,
ITOH YUKIO,
WADA RYO,
NAGAO KEIJI,
FUJIME MAKOTO
Publication year - 2006
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2006.01328.x
Subject(s) - embryonal carcinoma , medicine , bleomycin , etoposide , human chorionic gonadotropin , lymph , cisplatin , pathology , carcinoma , chemotherapy , hormone , cellular differentiation , gene , biology , biochemistry
A burned‐out testicular tumor with lung and lymph node metastases presented high serum levels of DU‐PAN‐2. However, the serum levels of CA19‐9, alpha‐fetoprotein, beta‐human chorionic gonadotropin, and sialyl Lewis X were normal. A biopsy of the cervical lymph nodes revealed embryonal carcinoma. Four courses of chemotherapy, including cisplatin, etoposide, and bleomycin, normalized the level of DU‐PAN‐2, and the metastatic lesions disappeared. This is the second reported case of an embryonal carcinoma producing DU‐PAN‐2. The secretor and Lewis gene typings, which affect the normal serum ranges of CA19‐9 and DU‐PAN‐2, were determined.