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Interferon‐related mental deterioration after craniotomy for removal of metastatic renal cancer
Author(s) -
TAKAHASHI SATORU,
YOKOYAMA HIROSHI,
YANAI YOSHIAKI,
KURIMOTO MASASHI,
OHTA NOBUTAKA,
KITAMURA TADAICHI
Publication year - 2006
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2006.01284.x
Subject(s) - medicine , craniotomy , discontinuation , alpha interferon , renal cell carcinoma , alpha (finance) , cerebrospinal fluid , adverse effect , interferon , nephrectomy , interferon alfa , cancer , kidney , anesthesia , surgery , immunology , construct validity , patient satisfaction
Interferon‐related severe adverse events on the central nervous system are relatively rare, because interferon‐α (INF‐α) can not cross an intact blood–brain barrier. We experienced remarkable mental deterioration caused by INF‐α administration in a 43‐year‐old man with renal cell carcinoma after surgical removal of a metastatic brain tumor. We detected a high concentration of INF‐α in a cerebrospinal fluid sample, which was comparable to that in the serum at 24 h after the administration of INF‐α; 5 × 10 6 IU i.m., suggesting that the blood–brain barrier was damaged somehow by the craniotomy. The mental deterioration improved shortly after discontinuation of the INF‐α administration.