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Outcome analysis for conservative management of Peyronie's disease
Author(s) -
HASHIMOTO KOHEI,
HISASUE SHINICHI,
KATO RYUICHI,
KOBAYASHI KO,
SHIMIZU TAKASHI,
TSUKAMOTO TAIJI
Publication year - 2006
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2006.01270.x
Subject(s) - medicine , peyronie's disease , conservative management , multivariate analysis , conservative treatment , symptom relief , vitamin d and neurology , disease , surgery , significant difference
Background: We retrospectively analysed the outcomes of conservative management of Peyronie's disease and determined the factors predicting successful outcome. Methods: The study involved 31 patients with Peyronie's disease who were treated at our institute between 1985 and 2003. We assessed the efficacy of vitamin E for the improvement of the symptoms, and the factors which contributed to successful outcome with conservative management using multivariate analysis. Results: There was no statistically significant difference in the relief rate between the vitamin E and no‐medication groups. The overall estimated relief rate was 67.5% at 2 years from presentation. The multivariate analysis revealed plaque size to be the only significant factor predicting the relief from all symptoms in patients with conservative management. The rate was 100% in patients having a plaque size of 20 mm or smaller and 20.0% in those having a size of larger than 20 mm ( P = 0.005). Conclusions: We could not confirm the benefit of vitamin E for Peyronie's disease. Plaque size was the only significant factor predicting the relief from all symptoms. Patients with larger plaque might fail to respond to the conservative management.