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Clinical study of six cases showing late relapse of germ cell tumors
Author(s) -
MURAMAKI MOTOTSUGU,
HARA ISAO,
MIYAKE HIDEAKI,
YAMADA YUJI,
KAWABATA GAKU,
KAMIDONO SADAO
Publication year - 2005
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2005.01158.x
Subject(s) - medicine , seminoma , germ cell , germ cell tumors , chemotherapy , disease , incidence (geometry) , oncology , germinoma , surgery , biology , biochemistry , physics , optics , gene
Late relapse of germ cell tumors has been considered rare. We report six patients treated at our institution with relapses of germ cell tumors more than 2 years after first successful management. Median time to late relapse for pure seminomas and non‐seminomatous germ cell tumors was 30.0 and 75.5 months, respectively. The sites of the late relapses in two cases of pure seminoma were located out of the fields of irradiation. After systematic chemotherapy, both these patients remain disease free. Two patients with non‐seminomatous germ cell tumors received salvage chemotherapy at the time of late relapse, but tumor markers did not normalize in either case. A complete resection of relapsed masses was performed in three cases of non‐seminomatous germ cell tumors. All three patients are without evidence of disease. The incidence of late relapse in patients with pure seminomas and non‐seminomas was 2.4% and 3.3%, respectively, which suggests the necessity for long‐term follow up.