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Bladder cancer discovered by ovarian metastasis: Cytokeratin expression is useful when making differential diagnosis
Author(s) -
ISHII YASUHIKO,
ITOH NAOKI,
TAKAHASHI ATSUSHI,
MASUMORI NAOYA,
IKEDA TATSURU,
TSUKAMOTO TAIJI
Publication year - 2005
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2004.00972.x
Subject(s) - medicine , cytokeratin , differential diagnosis , metastasis , bladder cancer , ovarian cancer , differential (mechanical device) , pathology , cancer , oncology , immunohistochemistry , engineering , aerospace engineering
A 49‐year‐old woman underwent hysterectomy and bilateral adnexectomy after the diagnosis of a right ovarian tumor with paraaortic and pelvic lymph node metastases. The pathological diagnosis was undifferentiated carcinoma of the ovary. After the operation, a bladder tumor was discovered during the evaluation for microscopic hematuria. The bladder tumor was pathologically diagnosed as transitional cell carcinoma, pT1b, G3. Although the pathological findings of the bladder cancer and ovarian cancer were very similar, we could diagnose primary bladder cancer with ovary and lymph node metastases according to the immunohistochemical staining pattern of cytokeratins 7 and 20. Herein, the clinical usefulness of immunohistochemical staining using cytokeratins for making a differential diagnosis of the origin of a tumor in the pelvic cavity is demonstrated.