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Enhancement of T cell proliferative response against autologous cancer cells of a metasatic renal cell carcinoma patient after unexplained regression
Author(s) -
KAWAI KOJI,
SAIJO KAORU,
OIKAWA TAKEHIRO,
OHNO TADAO,
AKAZA HIDEYUKI
Publication year - 2004
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2004.00954.x
Subject(s) - medicine , renal cell carcinoma , oncology , cancer , cell , cancer cell , regression , carcinoma , cancer research , statistics , genetics , mathematics , biology
The unexplained regression of a metastasis of renal cell carcinoma (RCC) is rare phenomenon. While an immune mechanism has been proposed for spontaneous or unexplained regression of RCC, only limited data are available regarding immunological response. We report a case of a 62‐year‐old man with RCC whose paravertebral pleural tumor regressed after the withdrawal of interferon‐α. In the present case, we demonstrate the enhancement of T cell proliferative response against autologous RCC cells secondary to the unexplained regression using the mixed‐lymphocyte tumor culture. To our knowledge, the enhancement of an antitumor immunity secondary to an unexplained regression of RCC has not previously been reported.