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Medical management of recurrent aggressive angiomyxoma with gonadotropin‐releasing hormone agonist
Author(s) -
SHINOHARA NOBUO,
OMURA KATSUYA,
ISHIKAWA SHUHEI,
SEKI HARUO,
KOYANAGI TOMOHIKO
Publication year - 2004
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2004.00816.x
Subject(s) - aggressive angiomyxoma , medicine , agonist , gonadotropin releasing hormone agonist , gonadotropin releasing hormone , hormone , gynecology , surgery , perineum , receptor , luteinizing hormone
Patients with aggressive angiomyxoma may experience local recurrences. We report a case of recurrent aggressive angiomyxoma medically treated successfully with a gonadotropin‐releasing hormone agonist. A 34‐year‐old woman with a huge perineal tumor underwent an extensive resection of the abdominoperineal tumor combined with total pelvic exenteration. Histology showed aggressive angiomyxoma and the tumor cells were immunoreactive for estrogen and progesterone receptors. Although the patient had experienced no local recurrence for 12 months under adjuvant therapy with a gonadotropin‐releasing hormone agonist, a recurrence occurred 3 months after the completion of adjuvant therapy. The patient underwent medical treatment with a gonadotropin‐releasing hormone agonist and had a complete resolution of the recurrent tumor again. Hormonal treatment with a gonadotropin‐releasing hormone agonist can be applied for small primary aggressive angiomyxomas in addition to adjuvant therapy for residual tumors.