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Polymerase Chain Reaction Analysis of the Y Chromosome Long Arm in Azoospermic Patients: Lack of the Y Chromosome Recognition Motif (YRRM1) Gene
Author(s) -
Baba Katsuyuki,
Iwamoto Teruaki,
Nakagome Yasuo,
Kuroki Yoko,
Nakahori Yutaka,
Yajima Michitaka,
Tanaka Hiroki,
Osada Takao
Publication year - 1998
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.1998.tb00403.x
Subject(s) - gene , locus (genetics) , long arm , genetics , y chromosome , azoospermia , polymerase chain reaction , azoospermia factor , chromosome , medicine , microbiology and biotechnology , biology , infertility , pregnancy
We analyzed DNA from a patient with azoospermia whose Y chromosome was cytogenetically normal. A total of 16 loci on the Y chromosome long arm were examined: 15 loci between DYS7E and DYZ1, and the Y chromosome RNA recognition motif (YRRM1) locus, a candidate gene for the azoospermic factor AZF. We did not detect the YRRM1 gene in this patient. This finding supports the theory that YRRM1 is an essential gene for spermatogenesis.