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Differential Expression of Hepatocyte Growth Factor in Papillary and Nodular Tumors of the Bladder
Author(s) -
Li Benyi,
Kanamaru Hiroshi,
Noriki Sakon,
Fukuda Masaru,
Okada Kenichiro
Publication year - 1998
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.1998.tb00383.x
Subject(s) - medicine , hepatocyte growth factor , pathology , differential (mechanical device) , differential diagnosis , expression (computer science) , cancer research , receptor , computer science , engineering , programming language , aerospace engineering
Background: The aim of this study was to investigate the expression of hepatocyte growth factor (HGF) and its receptor (c‐met) during bladder tumorigenesis. Methods: HGF and c‐met expression were analyzed immunohistochemically in matched samples of normal, dysplastic, and carcinoma specimens from 49 human bladders resected at the time of radical cystectomy for nonmetastatic transitional cell carcinoma (TCC). The tumors were composed of papillary (n = 22), nodular (n = 16) or mixed papillary and nodular (mixed; n = 11) components. Results: The normal urothelium showed no significant immunoreactivity to HGF. Expression of HGF was observed in 45.5%, 77.3% and 90.9% of specimens demonstrating mild, moderate, and severe dysplastic lesions adjacent to papillary TCCs, respectively, whereas all of the papillary TCC samples were positive for HGF. No immunoreactivity for HGF was found in dysplastic lesions from nodular tumors, and only 2 specimens had positive immunostainingfor HGF in the tumor areas (1 showed weak immunostainingand 1 showed HGF immunostainingonly in the deeper invasive compartment). Additionally, 3 nodular lesions taken from mixed tumors showed weak immunostaining for HGF while the concurrent papillary lesions were HGF‐positive. There was a significant difference of HGF immunoreactivity between papillary and nodular tumors (P < 0.01). c‐met immunostaining was consistently detected in all specimens. HGF and c‐met immunoreactivity did not significantly correlate with tumor stage and grade, nor with overall patient survival irrespective of the tumor growth pattern. Conclusion: These results suggest that HGF expression may play a significant role in the development of papillary TCC.