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Therapeutic Efficacy of Clenbuterol for Urinary Incontinence after Radical Prostatectomy
Author(s) -
Noguchi Masanori,
Eguchi Yoshiro,
Ichiki Junji,
Yahara Junro,
Noda Shinshi
Publication year - 1997
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.1997.tb00289.x
Subject(s) - medicine , clenbuterol , prostatectomy , urology , urinary incontinence , prostate cancer , cancer
Background : Urinary incontinence is one of the most common complications occurring after radical prostatectomy. We evaluated the efficacy of clenbuterol, a selective β 2 ‐adrenoceptor agonist, in the treatment of incontinence occurring after radical prostatectomy, using urodynamic assessment. Methods : Fourteen men (mean age, 68 years) with post‐radical‐prostatectomy incontinence were treated with 20 mg of clenbuterol twice a day for 1 month. The urodynamic assessment was performed on all patients before and after the administration of clenbuterol. A pad scoring system was used to gauge the severity of incontinence before and after treatment. Results : At 1 month after administration of clenbuterol, 9 of the 14 patients (64%) had dramatic improvement in pad scores. Treatment failed in 5 patients (36%) with severe incontinence. The results of urodynamic studies showed that the mean functional urethral length of the patients with post‐radical‐prostatectomy incontinence increased significantly after treatment. Conclusion : These results suggest that clenbuterol can be used as an effective agent for treating mild‐to‐moderate stress incontinence after radical prostatectomy.