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Preoperative Localization of Parathyroid Adenomas Using 99m Tc‐MIBI Scintigraphy in Patients with Hyperparathyroidism
Author(s) -
Ebisuno Shoichi,
Inagaki Takeshi,
Yoshida Toshihiko,
Yamamoto Motoki,
Tabuse Yoji,
Kohjimoto Yasuo,
Ohkawa Tadashi
Publication year - 1997
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.1997.tb00157.x
Subject(s) - medicine , scintigraphy , hyperparathyroidism , nuclear medicine , primary hyperparathyroidism , radiology , subtraction , thallium , technetium , technetium (99mtc) sestamibi , technetium 99m , technetium tc 99m sestamibi , chemistry , inorganic chemistry , arithmetic , mathematics
Background Technetium (Tc) 99m methoxyisobutyl isonitrile ( 99m Tc‐MIBI) has recently been introduced for parathyroid imaging, as well as for myocardial imaging. We studied the usefulness of 99m Tc‐MIBI scintigraphy for preoperative localization of abnormal parathyroid glands. Methods The usefulness of 99m Tc‐MIBI scintigraphy for detection of hyperfunctional parathyroid lesions was evaluated in 5 patients with primary hyperparathyroidism. The results of localizing the abnormal glands by using 99m Tc‐MIBI were compared with those obtained by using thallium (Tl) 201‐technetium (Tc) 99m ( 2ul TI‐ 99m Tc) subtraction scintigraphy, computed tomography, and ultrasonography. Results The delayed (2 hours) imaging of 99m Tc‐MIBI scintigraphy was highly useful for accurate localization of the abnormal parathyroid lesions. The diseased glands were detected in all cases where 99m Tc‐MIBI scintigraphy was used, and using 99m Tc‐MIBI scintigraphy provided more information than did computed tomography, ultrasonography, or 201 Tl‐ 99m Tc subtraction scintigraphy. Conclusion: This method is simple and essential for detecting hyperfunctioning parathyroid glands, especially those with small or ectopic lesions. This technique should be widely applied as a localizing diagnostic method for hyperparathyroidism.