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Cisplatin, Vincristine, Methotrexate, Peplomycin, Etoposide (COMPE) Therapy for Disseminated Germ Cell Testicular Tumors
Author(s) -
Yoshimura Koji,
Yamauchi Tamio,
Maeda Hiroshi
Publication year - 1997
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.1997.tb00139.x
Subject(s) - etoposide , medicine , methotrexate , cisplatin , vincristine , oncology , germ cell tumors , chemotherapy , urology , cancer research , cyclophosphamide
Background The advent of cisplatin rendered disseminated testicular germ cell tumor an often curable malignant disease. Patients with a heavy metastatic burden, however, remain poor risks; furthermore, many patients experience nausea or other adverse events. This paper reports a trial of a cisplatin‐based (COMPE) combination chemotherapy regimen based on synchronization theory. Methods Twenty patients with disseminated germ cell testicular tumors were treated with COMPE; any residual tumor mass was surgically resected. Results Seventeen patients (85%) achieved complete remission by chemotherapy. The actuarial overall and cause‐specific 3‐year survival rates were 89% and 94%, respectively. In the subset of 16 “good‐risk” patients, all remain alive after a median follow‐up of 43 months. Complications were quite tolerable, with nephrotoxicity in particular being extremely mild. Conclusion COMPE is an effective chemotherapy regimen in patients with disseminated germ cell testicular tumors. Complications arising from this therapy are mild.