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Risk Factors in Urinary Calcium Oxalate Stone Formation and their Relation to Urinary Calcium Oxalate Supersaturation
Author(s) -
Ogawa Yoshihide,
Hatano Tadashi
Publication year - 1996
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.1996.tb00553.x
Subject(s) - supersaturation , calcium oxalate , calcium , oxalate , hypercalciuria , medicine , urinary calcium , urine , urinary system , chemistry , inorganic chemistry , organic chemistry
Background: We studied the effect of potential risk factors of urinary calcium oxalate saturation on calcium oxalate stone formation. Methods: Using the Equil2 program, the DG values of calcium oxalate in 390 clinical urine specimens were estimated in 5 healthy male individuals with and without citrate therapy. Results: Critical calcium‐oxalate supersaturation (DG value, > 2.8) was noted in 15 out of 390 urine specimens. Of the 15, 14 late night or morning specimens had critical calcium oxalate supersaturation, while only 1 afternoon specimen was supersaturated. Critical calcium oxalate supersaturation was often associated with hyperoxaluria and hypercalciuria, while undersaturation was often associated with hypomagnesiuria, a high Ca/Mg ratio, and hypocitraturia. Conclusions: Hypomagnesiuria, hypocitraturia, and a high Ca/Mg ratio appear to be poor indicators of calcium‐oxalate supersaturation, and it is hard to predict the level of calcium‐oxalate saturation using single parameters.