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Sodium Chloride–Dependent Oxalate Absorption in the Human Gut
Author(s) -
Yamakawa Kensuke,
Kato Takahiro,
Kawamura Juichi
Publication year - 1996
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.1996.tb00350.x
Subject(s) - oxalate , sodium , sodium oxalate , medicine , calcium oxalate , calcium , chloride , endocrinology , zoology , chemistry , inorganic chemistry , biology , organic chemistry
We investigated the effect of sodium chloride intake on oxalate and calcium metabolism in the human body. In healthy subjects with a simultaneous intake of sodium oxalate (4 μmoles/kg body weight) and sodium chloride (1.2 mmoles/kg body weight), the change in oxalate–creatinine ratio was 2.04 ± 0.74, and 3.25 ± 1.29 (means ± SD), respectively, after 2 and 4 hours of oxalate intake (n= 8). The magnitude of the change in the ratio was significantly greater in the case with simultaneous intake of sodium chloride and sodium oxalate in comparison to the case with an intake of sodium oxalate alone ( P < 0.05 and P < 0.01 after 2 and 4 hours of intake of oxalate, respectively). In subjects with an intake of sodium chloride alone, the change in calcium–creatinine ratio was 49.07 ± 29.96 and 0.363 ± 0.309 (means ± SD), respectively, after 2 and 4 hours of sodium chloride intake (n= 3). The results suggest that high sodium intake can be one of the risk factors for urolithiasis.