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Production of Heparan Sulfate in the Process of Calcium Oxalate Microlith Formation
Author(s) -
Nishio Shunji,
Sato Takeshi,
Yokoyama Masayoshi,
Iwata Hidenobu,
Takeuchi Masafumi
Publication year - 1996
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.1996.tb00092.x
Subject(s) - heparan sulfate , calcium oxalate , glycosaminoglycan , calcium , immunoelectron microscopy , oxalate , medicine , biochemistry , microbiology and biotechnology , chemistry , immunology , antibody , biology , inorganic chemistry
To evaluate the interaction in the renal tubules between calcium oxalate microliths and glycosaminoglycans, especially heparan sulfate, we planned an experimentally–induced calcium oxalate microlith–producing model in rats. We found by immunofluorescence study and immunoelectron microscopy using the heparan sulfate antibody that heparan sulfate was produced in the renal tubular cells in the formation of calcium oxalate microliths and that heparan sulfate exists in the microliths. Heparan sulfate/crystal interaction might play a role as a nucleating agent and promote stone enlargement.