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INTERFERON‐GAMMA AND INTERLEUKIN‐2 SUPPRESS THE EXPERIMENTAL METASTASIS OF MOUSE RENAL ADENOCARCINOMA
Author(s) -
Masumori Naoya,
Tsukamoto Taiji,
Kumamoto Yoshiaki
Publication year - 1995
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.1995.tb00612.x
Subject(s) - medicine , metastasis , renal cell carcinoma , adenocarcinoma , cancer research , pulmonary adenocarcinoma , interferon , interferon gamma , alpha interferon , cytokine , cancer , immunology
While cytokines such as interferon‐alpha (IFN‐α), interferon‐gamma (IFN‐γ) and interleukin‐2 (IL‐2) are partially effective in the treatment of metastatic renal cell carcinoma, these cytokines have not been investigated for their ability to suppress the development of metastasis. We investigated whether they suppressed experimental pulmonary metastasis by subline‐2 of streptozotocin‐induced mouse renal adenocarcinoma (MRAC‐PM2). IFN‐γ (1 × 10 4 and 1 × 10 5 U/mouse) and IL‐2 (1 × 10 4 and 1 × 10 5 U/mouse) suppressed the experimental pulmonary metastasis of MRAC‐PM2 in a dose‐dependent manner, but 1 × 10 5 lU/mouse of IFN‐α did not. The combination of 1 × 10 5 U IFN‐γ with 1 × 10 5 U IL‐2 had the most powerful inhibitory effect on pulmonary metastasis without any side‐effects. In addition, the combination of 1 × 10 5 U IFN‐γ with 1 × 10 5 U IL‐2 had a synergistic inhibitory effect on the growth of subcutaneous tumors. These results indicate that either IFN‐γ or IL‐2, or their combination, produce a more favorable effect than IFN‐α on the metastatic development of renal adenocarcinoma.