Premium
Hypophosphatemia among severely malnourished children with sepsis in B angladesh
Author(s) -
Yoshimatsu Shoji,
Hossain Md Iqbal,
Islam Md Munirul,
Chisti Mohammod Jobayer,
Okada Masafumi,
Kamoda Tomohiro,
Fukushima Takashi,
Wagatsuma Yukiko,
Sumazaki Ryo,
Ahmed Tahmeed
Publication year - 2013
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.2012.03724.x
Subject(s) - medicine , hypophosphatemia , sepsis , confidence interval , odds ratio , gastroenterology , logistic regression , malnutrition , potassium phosphate , chromatography , chemistry
Background The interaction between hypophosphatemia ( HP ) and severe malnutrition has received little attention. This study investigated the prevalence, severity, and risk factors of HP among severely malnourished children with sepsis in B angladesh. Methods Children aged 6–59 months admitted with sepsis to D haka H ospital from A pril 2010 to D ecember 2011 were enrolled in the study and divided into two groups: severe acute malnutrition ( SAM ) and non‐ SAM groups. Plasma phosphate and the related biochemical parameters were measured upon admission and on the second and fourth days for both groups and the 10th day or discharge day for the SAM group. Results The prevalence of HP (plasma phosphate <3.7 mg/dL) was 72.9% and 62.5% ( P = 0.26) for 48 SAM and for 56 non‐ SAM patients, respectively; that of moderate–severe HP (phosphate <2 mg/dL) was 25.0% and 19.6%, respectively ( P = 0.51). The plasma phosphate level of 21 SAM patients was significantly lower on the second and fourth days than upon admission ( P = 0.03, P = 0.01, respectively); it then recovered on the 10th day or discharge day. On multiple logistic regression analysis, plasma potassium <2.5 mmol/L upon admission was found to be a risk factor for moderate or severe HP (adjusted odds ratio, 7.21; 95% confidence interval: 1.88–27.7). Conclusion HP is common among children with sepsis. Potassium <2.5 mmol/L upon admission is considered a risk factor for moderate or severe HP in children with sepsis.