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Association between bronchopulmonary dysplasia and MBL2 and IL1‐RN polymorphisms
Author(s) -
Cakmak Bilin Cetinkaya,
Calkavur Sebnem,
Ozkinay Ferda,
Koroglu Ozge Altun,
Onay Huseyin,
Itirli Gulcin,
Karaca Emin,
Yalaz Mehmet,
Akisu Mete,
Kultursay Nilgün
Publication year - 2012
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.2012.03714.x
Subject(s) - bronchopulmonary dysplasia , medicine , genotype , mannan binding lectin , odds ratio , genetic predisposition , gastroenterology , immunology , confidence interval , gene , gestational age , pregnancy , genetics , biology , lectin , disease
Background The imbalance between pro‐inflammatory and anti‐inflammatory cytokines may play a role in the development of bronchopulmonary dysplasia ( BPD ) in preterm infants. Mannose binding lectin ( MBL ) codon 54 and interleukin 1 receptor antagonist gene ( IL1‐RN ) polymorphisms cause genetic predisposition to increased risk of infection and inflammation, therefore may increase the risk of BPD . The aim of this study was to investigate the relationship between MBL , IL1‐RN gene polymorphisms and BPD development in preterm infants. Methods MBL codon 54 and IL1‐RN polymorphisms were studied in 71 infants who were born at <32 weeks of gestation, with the diagnosis of BPD ( group 1) and in a control group of preterm infants without BPD ( group 2). Results IL1‐RN and MBL2 variant genes were closely associated with increased risk of BPD (both P < 0.001) together with significantly lower birthweight ( P < 0.001 and P = 0.001, respectively), lower 5 min A pgar scores ( P = 0.009 for both genes) and increased neonatal infection rate ( P < 0.001 and P < 0.009, respectively). The IL 1 RN 1/1 genotype was protective (odds ratio [ OR] , 0.075; 95% confidence interval [ CI]: 0.019–0.76) while the IL1‐RN 2/2 genotype increased the risk for BPD ( OR , 11.7; 95% CI : 1.3–103.6). The MBL‐AA genotype was protective against BPD ( OR , 0.066; 95% CI : 0.02–0.2) whereas the MBL‐BB genotype increased the susceptibility for the development of BPD ( OR , 23.8; 95% CI : 2.8–200.6). Conclusion MBL and IL 1 RN polymorphisms are closely related to low birthweight and increase the risk of neonatal sepsis and BPD development in preterm infants.