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Chromium levels in healthy and newly diagnosed type 1 diabetic children
Author(s) -
Karagun Barbaros Sahin,
Temiz Fatih,
Ozer Guler,
Yuksel Bilgin,
Topaloglu Ali Kemal,
Mungan Neslihan Onenli,
Mazman Muhsin,
Karagun Gokhan Murat
Publication year - 2012
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.2012.03696.x
Subject(s) - medicine , gastroenterology , chromium , organic chemistry , chemistry
Background: The aim of this study was to compare the chromium levels of plasma (PCL), erythrocyte (ECL) and urine (UCL) in type 1 diabetics and healthy subjects and to review the relation between metabolic parameters. Methods: We evaluated 165 subjects who were: newly diagnosed type 1 diabetics (group 1 [ n = 29]); previously diagnosed type 1 diabetics (group 2 [ n = 18]); non‐diabetic control subjects who were admitted and treated for any reason in hospital (group 3 [ n = 21]); and two other groups of control subjects from two schools that have different socioeconomic levels (group 4 [ n = 48] and group 5 [ n = 49]). Results: PCL in group 1 and group 2 subjects (7.21 ± 4.78 and 10.94 ± 3.04 mcg/L, respectively) was significantly lower than in all control groups (21.84 ± 7.87, 16.11 ± 7.44, 17.25 ± 8.58 mcg/L, respectively) ( P < 0.05). A significant difference in PCL between the group 1 and group 2 subjects was present (7.21 ± 4.78 and 10.94 ± 3.04, respectively) ( P = 0.021). ECL (as tissue chromium) in group 1 and group 2 subjects (13.99 ± 11.37 and 19.64 ± 12.58, respectively) was significantly lower than in all control groups (28.20 ± 7.34.25, 49 ± 12.47, 26.37 ± 9.77 mcg/L, respectively) ( P = 0.05). UCL in group 1 and group 2 subjects (11.44 ± 6.88 and 15.68 ± 6.75 mcg/L, respectively) was significantly lower than in group 3 subjects (28.83 ± 9.37mcg/L) ( P < 0.05). There were significant correlations between length, bodyweight and PCL in the group 1 subjects (r = 0.42, P = 0.22 and r = 0.53, P = 0.03, respectively). There was a negative correlation between plasma glucose and UCL, which was not statistically significant in group 2 subjects (r =−0.4, P = 0.061). Conclusion: There was a negative chromium balance in type 1 diabetics. This negative balance may affect the insulin function badly. If this negative balance should be confirmed by recent studies we suggest that chromium supplementation with insulin is necessary for type 1 diabetes.