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Langerhans cell histiocytosis case with dense metaphyseal band sign
Author(s) -
Kikkawa Ichiro,
Aihara Toshinori,
Morimoto Akira,
Watanabe Hideaki,
Furukawa Rieko
Publication year - 2013
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.2012.03618.x
Subject(s) - medicine , langerhans cell histiocytosis , zoledronic acid , bone pain , vertebra , eosinophilic granuloma , bone disease , surgery , osteoporosis , pathology , disease
Eosinophilic granuloma, a type of Langerhans cell histiocytosis, exhibits a classic vertebral collapse, which is called vertebra plana (Calve's disease) and it manifests as a solitary bony lesion. Vertebra plana can cause severe pain in patients. Bisphosphonates (clodronate, pamidronate and zoledronic acid) have been recently used to treat osteolytic bone lesions of LCH. Zoledronic acid has 100 times relative potency that of pamidronate. We report a case of a 10‐year‐old girl who had zoledronic acid treatment for severe back pain due to vertebra plana. X‐ray photographs of the patient's body showed dense metaphyseal band sign, which can be found in lead poisoning, treated leukemia, healing rickets, recovery from scurvy, vitamin D hypervitaminosis, congenital hypothyroidism and hypoparathyroidism. Increased biological potent zoledronic acid deprived her of severe back pain due to vertebra plana and might cause dense metaphyseal band sign of her skeleton. Conclusion; We have cured the severe back pain of a 10‐year‐old girl case of eosinophilic granuloma with zoledronic acid. After that treatment, X‐ray photographs of the patient's body showed dense metaphyseal band sign. There have been few such cases reported until now.