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Neonatal renal venous thrombosis followed by secondary pseudohypoaldosteronism
Author(s) -
Nakashima Hideyuki,
Kibe Tetsuya,
Ohro Yoichiro,
Fujita Naoya
Publication year - 2012
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.2012.03617.x
Subject(s) - medicine , pseudohypoaldosteronism , hyperkalemia , hyponatremia , metabolic acidosis , plasma renin activity , aldosterone , sodium bicarbonate , venous thrombosis , acidosis , sodium , thrombosis , renin–angiotensin system , endocrinology , cardiology , blood pressure , chemistry , organic chemistry
A male infant was diagnosed as having renal venous thrombosis (RVT) in association with bilateral flank masses, macroscopic hematuria, and thrombocytopenia. In the course of supportive treatment, hyponatremia, hyperkalemia, and metabolic acidosis became prominent. Plasma renin activity (PRA) and aldosterone increased markedly. Treatment with sufficient sodium chloride and sodium bicarbonate intake was effective. It is important to note that tubular damage by RVT causes secondary pseudohypoaldosteronism.