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Insulin resistance at diagnosis in Japanese children with type 2 diabetes mellitus
Author(s) -
Urakami Tatsuhiko,
Habu Masako,
Kuwabara Remi,
Komiya Kei,
Nagano Nobuhiko,
Suzuki Junichi,
Mugishima Hideo
Publication year - 2012
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.2012.03596.x
Subject(s) - medicine , insulin resistance , overweight , insulin , type 2 diabetes mellitus , diabetes mellitus , endocrinology , homeostasis , obesity , type 2 diabetes , plasma glucose , group b , gastroenterology
Background: Insulin resistance at diagnosis was investigated in Japanese children with type 2 diabetes mellitus (T2DM). Methods: A total of 160 children with T2DM were divided into groups on the basis of percent overweight at time of diagnosis: group A ( n = 28), <20%; group B ( n = 55), 20–39%; group C ( n = 37), 40–59%; group D ( n = 40), ≥60%. Indicators of insulin resistance at diagnosis were compared among the four patient groups, and also between the children with T2DM and the 201 age‐matched normal Japanese children. Results: There were no significant differences in plasma glucose (PG) levels among the four patient groups. The mean concentration of fasting plasma immunoreactive insulin (IRI) was significantly higher in group D than in groups A and B (39.2 µU/mL vs 16.2 µU/mL and 24.1 µU/mL, P < 0.05, respectively). The mean homeostasis model assessment (HOMA‐R) was significantly higher in group D than in all the other three groups (17.6 vs 7.8, 10.8 and 12.7, P < 0.05, respectively). The indicators HOMA‐R and fasting IRI were significantly higher in each diabetes group, even in non‐obese group A, than in normal children ( P < 0.01, respectively). Conclusions: Japanese children with T2DM had insulin resistance at diagnosis regardless of percent overweight, and the degree of insulin resistance gradually increased with rise in percent overweight.