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Castleman disease in a child with short stature
Author(s) -
Hanada Takuya,
Okuno Keisuke,
Okada Shinichi,
Fujimoto Masanobu,
Kuranobu Hiroki,
Hashida Yuichiro,
Ueyama Junichi,
Murakami Jun,
Hayashi Atsushi,
Hanaki Keiichi,
Kanzaki Susumu
Publication year - 2012
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.2012.03589.x
Subject(s) - medicine , thrombocytosis , short stature , castleman disease , pathological , erythrocyte sedimentation rate , hypochromic anemia , microcytic anemia , anemia , hypergammaglobulinemia , disease , gastroenterology , pathology , endocrinology , platelet
We report a 14‐year‐old boy with Castleman disease in this article. He complained of short stature, and his body height was 133.8 cm (<3rd percentile; z score −4.5). There was marked delay in the appearance of secondary sexual characteristics. He was found to have a remittent fever and a lower mid‐abdominal tumor. Blood test revealed microcytic hypochromic anemia, thrombocytosis, polyclonal hypergammaglobulinemia, hyperfibrinogenemia, and elevated erythrocyte sedimentation rate. The serum IL‐6 and C‐reactive protein levels were increased. The mass was found to be mixed hyaline vascular and plasma cell type of Castleman disease through a pathological examination. Lymph nodes affected by Castleman disease cause overproduction of IL‐6. It decreases IGF‐1, IGFBP‐3 and serum testosterone levels. As a result of tumorectomy, his short stature and delay in the development of secondary sexual characteristics were improved.