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Use of Cefoperazone/sulbactam in neonates
Author(s) -
Ovali Fahri,
Gursoy Tugba,
Sari Ilkay,
Divrikli Demet,
Aktas Alev
Publication year - 2012
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.2011.03458.x
Subject(s) - medicine , cefoperazone , sulbactam , antibiotics , microbiology and biotechnology , antibiotic resistance , biology , imipenem
Background: Neonates are at high risk for nosocomial infections due to multidrug‐resistant pathogens. The use of β‐lactamase inhibitors in combination with β‐lactam antibiotics broadens the antimicrobial spectrum. Cefoperazone/sulbactam is used in children but there are limited data on its usage in neonates. The purpose of the present study was therefore to evaluate the use of cefoperazone/sulbactam in the treatment of neonatal infections caused by multidrug‐resistant pathogens. Methods: The records of neonates who were hospitalized and who received cefoperazone/sulbactam were reviewed. Results: There were 90 infants who received cefoperazone/sulbactam. A pathogen could be isolated in 41 (45.6%) of the infants. In total, 17.1% of isolated pathogens were resistant to cefoperazone/sulbactam. Side‐effects were seen in four of the infants. Two infants had cholestasis, one infant had neutropenia and one had superinfection with candida. Conclusion: Cefoperazone/sulbactam can be used in the treatment of nosocomial infections caused by multidrug‐resistant pathogens in neonates.