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The relation of arterial stiffness with intrauterine growth retardation
Author(s) -
Levent Ertürk,
Atik Tahir,
Darcan Şükran,
Ülger Zülal,
Gökşen Damla,
Özyürek A. Ruhi
Publication year - 2009
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.2009.02905.x
Subject(s) - medicine , gestational age , arterial stiffness , body mass index , small for gestational age , cardiology , blood pressure , abdominal aorta , obstetrics , aorta , pregnancy , genetics , biology
Background: Much epidemiological evidence has linked low birthweight with late cardiovascular risk. Intrauterine growth retardation (IUGR) is associated with the increased risk of cardiovascular disease in adult life; it is unclear whether the relationship is present at younger ages. We evaluated whether abdominal aortic stiffness was altered in patients with IUGR (born at term with birthweight small for gestational age) in younger ages. Methods: Thirty‐two (24 girls and eight boys) IUGR children aged 8.77 ± 2.05 years were enrolled in the study. The birthweight was traced from the medical records. Their gestational ages were 38.9 ± 0.85 weeks and birthweights 2130 ± 198 g, respectively. Thirty‐one healthy subjects who had normal gestational age and birthweight, matched for age and sex were recruited as a control group. Aortic strain, pressure strain elastic modulus (Ep), and normalized Ep and aortic distensibility were measured by a sphygmomanometer and transthoracic echocardiography in all subjects from the abdominal aorta. Results: There was no statistically significant difference between the study and the control groups in sex, mean age, body mass index, lipid profile, leptin, insulin‐like growth factor‐1 or insulin‐like growth factor binding protein 3. In IUGR children, aortic strain (0.201 ± 0.027 vs 0.254 ± 0.031, P < 0.001) and aortic distensibility (1.08 ± 0.19 vs 1.42 ± 0.24, P < 0.001) were significantly lower compared with the control group. However Ep (188 ± 36.2 vs 146 ± 27.1, P < 0.001) and normalized Ep (2.97 ± 0.40 vs 2.1 ± 0.39, P < 0.001) were significantly higher in IUGR patients. Conclusions: This study demonstrates that abdominal aortic stiffness is increased in IUGR patients. These data suggest that prenatal events could be related to cardiovascular risk in later life.