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Children with type 2 diabetes mellitus are at greater risk of macrovascular complications
Author(s) -
Shiga Kentaro,
Kikuchi Nobuyuki
Publication year - 2009
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.2009.02836.x
Subject(s) - medicine , adiponectin , type 2 diabetes mellitus , macrovascular disease , plasminogen activator , endocrinology , risk factor , diabetes mellitus , type 2 diabetes , gastroenterology , insulin resistance , obesity
Background: Type 2 diabetes mellitus (DM) is a risk factor for macrovascular complications in adults. Recently young‐onset type 2 DM has increased worldwide and the increase of macrovascular complications in the young is worrisome. Methods: Plasma values for plasminogen activator inhibitor‐1 (PAI‐1) as a marker for promotion, and adiponectin as a marker for inhibition of atherosclerosis, were compared in 33 patients with type 1 DM (16 boys, 17 girls; age 14.9 ± 3.7 years, mean ± standard deviation) with those of 43 patients with type 2 DM (15 boys, 28 girls; age 16.5 ± 3.5 years). Results: The PAI‐1 level was significantly higher (19.3 ± 8.1 vs 32.9 ± 17.2 ng/ml; P < 0.001) and the adiponectin level was significantly lower (10.1 ± 3.8 vs 7.4 ± 3.7 µg/ml; P < 0.005) in the type 2 DM group. In obese patients, the PAI‐1 level was significantly higher ( P < 0.005) and the adiponectin level was lower ( P = 0.15) in the type 2 DM group. Also, in the non‐obese subjects, the PAI‐1 level was significantly higher ( P < 0.05) and the adiponectin level was lower ( P = 0.11) in the type 2 DM group. Conclusions: Even in young patients, type 2 DM is a risk factor for macrovascular complications compared with type 1 DM.