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Correlation of troponin I with perinatal and neonatal outcomes in neonates with respiratory distress
Author(s) -
Mu ShuChi,
Wang LingJen,
Chen YiLing,
Lin MingI,
Sung TsengChen
Publication year - 2009
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.2009.02817.x
Subject(s) - medicine , respiratory distress , apgar score , acidosis , birth weight , negative correlation , pediatrics , obstetrics , anesthesia , pregnancy , biology , genetics
Background: The specific aims of the present study were to evaluate the associations between cardiac troponin I (Tn I) and perinatal events and whether Tn I serves as a predictor to evaluate neonatal outcomes. Methods: Tn I level was assessed in sick neonates with respiratory distress within 12 h after birth. Apgar scores, acidosis, ventilator or oxygen requirement, hospital days and placenta clues were recorded. A total of 80 sick neonates were enrolled (54 preterm and 26 full‐term neonates) delivered at Shin‐Kong Wu Ho‐Su Memorial Hospital between July 2003 and December 2004. Results: There was a significant negative correlation between Apgar scores at 1 min and 5 min ( r =−0.383, P = 0.001; r =−0.500, P < 0.001), acidosis ( r =−0.309, P = 0.006), base excess ( r =−0.332, P = 0.003) and Tn I. The subjects were divided into two groups using the median level of 0.028 ng/mL as a cut‐off. There were significantly fewer neonates with high Apgar score (>7 at 5 min; 27/40, 69.2% vs 38/40, 97.4%; P = 0.001) in the higher Tn I group (≥0.028 ng/mL). Lower pH (7.4 ± 0.10 vs 7.3 ± 0.1, P = 0.011), lower base excess (−1.0 ± 4.3 vs −4.4 ± 5.1, P = 0.003) and less placental weight (548.8 ± 195.36 g vs 396.56 ± 154.30 g, P = 0.019) were also seen in the higher Tn I group. Conclusion: Tn I may play a role in the assessment of perinatal outcomes but is not a precise predictor of neonatal outcomes. Tn I level of 0.028 ng/mL is also suggested as a predictor of severity of perinatal outcomes in neonates with respiratory distress.