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Intravenous luteinizing hormone‐releasing hormone has no effect on serum N ‐terminal pro‐brain natriuretic peptide in children and adolescents
Author(s) -
Norozi Kambiz,
Binder Lutz,
Brack Christoph,
Potthoff Ludger,
Hess Georg,
Wessel Armin
Publication year - 2009
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.2008.02710.x
Subject(s) - medicine , hormone , luteinizing hormone , endocrinology , brain natriuretic peptide , natriuretic peptide , short stature , idiopathic short stature , heart failure , growth hormone
Background: Little is known about the acute effects of i.v. luteinizing hormone‐releasing hormone (LHRH) on the heart function, therefore the aim of the present study was to measure N ‐terminal pro‐brain natriuretic peptide (N‐BNP) in children, who underwent a diagnostic work up for short stature or delayed puberty. Methods: N‐BNP was measured in 52 children before and after administration of LHRH. Serum N‐BNP obtained from 255 healthy children and adolescents (aged birth–18.3 years) served as a reference. Results: There was no significant difference between baseline N‐BNP of children who underwent the LHRH diagnostic test and their healthy peers. There was no significant serum N‐BNP level change before or after administration of LHRH (59 ± 36 pg/mL vs 58 ± 34 pg/mL). N‐BNP fell from 399 ± 425 pg/mL in newborns and reached 44 ± 36 pg/mL in children aged 12–18 years. Conclusion: Short stature or delayed puberty had no effect on heart function determined by serum N‐BNP; i.v. LHRH does not acutely influence the level of serum N‐BNP.