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Role of angiotensin‐converting enzyme gene polymorphisms in children with sepsis and septic shock
Author(s) -
Cogulu Ozgur,
Onay Huseyin,
Uzunkaya Demet,
Gunduz Cumhur,
Pehlivan Sacide,
Vardar Fadil,
Atlihan Fusun,
Ozkinay Cihangir,
Ozkinay Ferda
Publication year - 2008
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.2008.02583.x
Subject(s) - sepsis , medicine , genotype , allele , immunology , gene , septic shock , immune system , angiotensin converting enzyme , genetics , biology , blood pressure
Background: Sepsis is characterized by a systemic inflammatory response. Its development and outcome are associated with host defense, pathogenicity of the microorganism and genetic polymorphisms. Genetic polymorphisms of the immune system genes have been shown to have a close relationship with the clinical outcomes of sepsis. Angiotensin‐converting enzyme (ACE) plays a major role in the host defense against invading pathogens. It is therefore likely that polymorphisms in the ACE gene may have an important effect on determining the development and the outcome of sepsis. Methods: Ninety‐eight children diagnosed as having sepsis and 287 healthy children were included in the study. Insertion/deletion polymorphisms were analyzed using reverse‐hybridization assay. Results: The carriers of I allele (D/I genotype and I/I genotype) were found to have an increased risk of developing sepsis compared to the controls. Conclusion: DD genotype may play a positive role against the development of sepsis in healthy children.