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T‐helper 1‐related chemokines in the exacerbation of childhood asthma
Author(s) -
Lai ShuTse,
Hung ChihHsing,
Hua YiMing,
Hsu ShihHsien,
Jong YuhJyh,
Suen JauLing
Publication year - 2008
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.2007.02533.x
Subject(s) - medicine , exacerbation , asthma , cxcl9 , cxcl10 , immunology , chemokine , monokine , corticosteroid , inflammation
Background: T‐helper (Th) 2 cytokines are thought to mediate most of the allergic inflammatory responses associated with atopic asthma. But the Th1‐related chemokine, interferon‐inducible protein 10 (IP‐10)/CXCL10, was the predominant chemokine measured during human allergic pulmonary late‐phase reaction. The aim of the present study was to evaluate the role of Th1‐ and Th2‐ related chemokines in the pathogenesis of asthma exacerbation. Methods: Plasma levels of the Th2‐related C‐C chemokine I‐309 (CCL1), the Th1‐related CXC chemokines IP‐10, and the monokine induced by interferon‐γ (Mig)/CXCL9 were measured in patients with stable asthma. Results: These results were compared to the results measured prior to, and after corticosteroid treatment, in patients who experienced asthma exacerbations. A significant increase in the plasma levels of IP‐10 and Mig, but not I‐309, were found in patients with an acute exacerbation in contrast to patients with stable asthma. Plasma levels of IP‐10 and Mig were significantly higher in patients during an acute asthma exacerbation than during a subsequent convalescent period. Conclusions: The Th1‐related CXC chemokines IP‐10 and Mig may be useful inflammatory markers of asthma exacerbation in children.