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Prothrombotic risk factors in children with hemiplegic cerebral palsy
Author(s) -
ŞENBIL NESRIN,
YÜKSEL DENIZ,
YILMAZ DENIZ,
GÜRER Y. K. YAVUZ
Publication year - 2007
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.2007.02424.x
Subject(s) - medicine , coagulopathy , cerebral palsy , factor v , pediatrics , protein c , risk factor , gastroenterology , thrombosis , physical therapy
Background: The purpose of the present paper was to investigate the prevalence of prothrombotic risk factors associated with hemiplegic cerebral palsy (CP). Methods: Twenty‐three hemiplegic CP patients were tested for inherited and acquired prothrombotic risk factors, except methylene tetrahydrofolate reductase (MTFR) polymorphism. Results: A total of 56.5% of patients had at least one coagulation abnormality and 13% of them had two. Four patients (8.7%) had infection and congenital heart disease, who also had additional coagulopathy risk factors. Obstetric problems were detected in 56.5%. Coagulopathy risk factors were factor V Leiden mutation (21.7%), protein C deficiency (21.7%), elevated lipoprotein‐a (13%), G20210A mutation of prothrombin (8.7%), and protein S deficiency (4.3%). Conclusion: Children with hemiplegic CP need to be evaluated for coagulopathic abnormalities.