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Seizures associated with poisoning in children: tricyclic antidepressant intoxication
Author(s) -
ÇITAK AGOP,
SOYSAL DEMET DEMIRKOL,
ÜÇSEL RAIF,
KARABÖCÜOGLU METIN,
UZEL NEDRET
Publication year - 2006
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.2006.02276.x
Subject(s) - medicine , status epilepticus , anesthesia , tricyclic antidepressant , epilepsy , poison control , pediatrics , tricyclic , drug overdose , retrospective cohort study , antidepressant , emergency medicine , psychiatry , hippocampus , pharmacology
Background: The aim of this study was to examine the characteristics of seizure due to poisoning. Methods: This was a retrospective analysis, throughout 4 years of hospital admissions for poisoning. Data of patients with seizures due to poisoning were evaluated with respect to the causes, frequencies and complications of seizures. Results: Among the 1561 admissions due to intoxication during the review period, seizures developed in 26 cases (1.6%). Tricyclic antidepressant overdose ( n = 11, 42%) was the leading cause of seizure due to poisoning. Generalized tonic‐clonic seizures were observed in 24 patients. Status epilepticus developed in six patients (23%). Mechanical ventilation was applied in 12 (46%) patients. Cardiac complications were observed in 11 (42%) patients with seizures. Two patients who had cardiac arrest due to acepromazin maleat and imipramine intoxication died. Conclusion: One of the causes of seizures in pediatric age group is intoxication. Seizures due to intoxications may cause serious clinical conditions. Intoxications should be thought when a patient is admitted with the diagnosis of afebrile seizure even if there is no history of drug intake.