Premium
Relationship of serum interleukin‐7 concentration and the coagulation state in children with nephrotic syndrome
Author(s) -
Wasilewska Anna,
ZochZwierz Walentyna M,
Tomaszewska Barbara,
Zelazowska Beata
Publication year - 2005
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.2005.02078.x
Subject(s) - medicine , thrombocytosis , nephrotic syndrome , fibrinogen , platelet , endocrinology , coagulation , albuminuria , interleukin , prednisone , urine , gastroenterology , immunology , renal function , cytokine
Background: Enhanced platelet reactivity may play a significant role in the hypercoagulable state of nephrotic syndrome (NS). Thrombocytosis with platelet aggregation cause the release of some cytokines, among them interleukin‐7 (IL‐7). The aim of the study was to evaluate serum IL‐7 levels in children with the symptoms of NS and to determine a correlation between its concentration and platelet count, other hemostatic factors, and NS intensity.Methods: The study was performed in two groups. I – the examined group of 26 children with NS (12 boys, 14 girls) aged 6.8 ± 2.1 years, subjected to two examinations: A – before treatment, B – during treatment with prednisone (60 mg/kg 24 h after albuminuria regression); and II – the control group (C) of 20 healthy children. Serum IL‐7 level was assayed by enzyme‐linked immunosorbent assay method using a R & D Quantikine set.Results: In group I, IL‐7 level in examination A (33.33 ± 33.24 pg/mL) was higher than in the control subjects ( P < 0.01). In examination B, IL‐7 concentration was reduced to the level of 10.86 ± 5.22 pg/mL and did not differ from the controls ( P > 0.05). A positive correlation was observed between IL‐7 and platelet count and serum fibrinogen level. A negative correlation was noted with antithrombin III concentration. No correlation was found with serum levels of albumin and cholesterol or urine protein.Conclusion: In children with NS, serum IL‐7 level increases proportionally to the elevated platelet count and other hemostatic components, but shows no correlation with serum albumin or urine protein.