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Behavioral outcome including attention deficit hyperactivity disorder/hyperactivity disorder and minor neurological signs in perinatal high‐risk newborns at 4−6 years of age with relation to risk factors
Author(s) -
Sato Masuko,
Aotani Hirofumi,
Hattori Ritsuko,
Funato Masahisa
Publication year - 2004
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.2004.01883.x
Subject(s) - medicine , attention deficit hyperactivity disorder , pediatrics , attention deficit , incidence (geometry) , apgar score , gestational age , pregnancy , psychiatry , physics , biology , optics , genetics
Background: Diagnostic problems with the criteria of attention deficit hyperactivity disorder (ADHD) in the Diagnostic Statistical Manual , 4th edn, have been identified. The aim of this study was to clarify whether the minor neurological signs test (MNT) the authors had previously reported was a predictor for the criteria of ADHD or hyperactivity disorder (HD) in perinatal risk children at 4−6 years of age and what kind of risk factors related to MNT 1 .Methods: A total of 136 children discharged from neonatal intensive care units were examined at the age of 4−6 years by a developmental neuropediatrician using both MNT and diagnostic criteria of DSM‐IV ADHD/ICD‐10 ( International Classification of Diseases , 10th edn) HD. SPSS base and professional were used for statistical analysis.Results: On comparison of diagnostic criteria between ADHD (11.0%) and HD (27.5%), the incidence in the same subjects showed significant difference. MNT scores showed significant correlation with criteria of ADHD ( P < 0.01) and HD ( P < 0.05). Diagnostic validity of MNT for predicting ADHD was demonstrated with 78% sensitivity and 79% specificity. High positive rates on MNT did not show a significant difference between the very low birthweight (VLBW) and non‐low birthweight (NLBW) groups. Behavioral outcome with relation to risk factors were analyzed using multiple regression analysis. Apgar 5 in the NLBW group and toxemia of pregnancy and small for gestational age (SGA) in VLBW group were highly correlated with behavioral outcome.Conclusions: Minor neurological signs test score was a significant predictor for criteria of ADHD and HD. High incidences of positive MNT were suspected in not only VLBW children but also NLBW children and Apgar 5 in NLBW children and toxemia of pregnancy and SGA in VLBW children influenced behavioral outcome.