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Staphylococcal enterotoxin‐specific IgE antibodies in atopic dermatitis
Author(s) -
Ide Fumihito,
Matsubara Tomoyo,
Kaneko Miho,
Ichiyama Takashi,
Mukouyama Tokuko,
Furukawa Susumu
Publication year - 2004
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.2004.01880.x
Subject(s) - medicine , immunoglobulin e , radioallergosorbent test , immunology , antibody , atopic dermatitis , exacerbation , allergy
Background: The authors clarified the clinical significance of the measurement of serum concentrations of specific IgE antibodies to staphylococcal enterotoxin (SE) A‐ and SEB in atopic dermatitis (AD).Methods: The serum concentrations of SEA‐ and SEB‐specific IgE antibodies in 140 pediatric patients with AD were measured with an immuno CAP −radioallergosorbent test system (RAST). To check the cross‐reaction of specific IgE antibodies to SEA/SEB and other allergens, the CAP RAST fluorescent enzyme immunoassay inhibition test was performed.Results: Forty‐seven patients (33.6%) tested positive for either SEA‐ or SEB‐specific IgE antibodies. School children showed higher positive rates of SEA/SEB‐specific IgE antibodies than infants or young children. The patients with severe AD and those with exacerbation of symptoms in summer, had higher positive rates of SEA/SEB‐specific IgE antibodies than patients with mild AD or those with exacerbation in winter. In addition, the positive rates of specific IgE antibodies to both dog‐dander and cat‐dander were higher in patients with positive SEA/SEB‐specific IgE antibodies than in patients with negative ones. No cross‐reactions occurred among specific IgE antibodies to SEA/SEB and dog/cat dander with one patient's serum, which had positive IgE‐specific antibodies against cat/dog dander and SEA/SEB. The positive rate of SEA/SEB‐specific IgE antibodies in the patients with dogs and/or cats as pets was 48.4%, which was higher than in those with no pets.Conclusions: Atopic dermatitis patients who exhibit high positive rates of SEA/SEB‐specific IgE antibodies were found to be school children, severe cases, cases with high serum concentrations of total IgE, cases with exacerbation in summer, and cases with dogs and/or cats as pets. The measurement of serum concentrations of specific IgE antibodies to SEA and SEB, thus has some value for evaluating AD patients.