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Prolonged suppressed thyroid‐stimulating hormone levels in hyperthyroidism in a neonate born to a mother with Graves' disease
Author(s) -
Hojo Minoru,
Momotani Naoko,
Ikeda Noriko,
Ueda Akihiko,
Uno Kuniko,
Ishikita Takashi,
Ishiguro Akira,
Shimbo Toshikazu
Publication year - 1998
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1998.tb01974.x
Subject(s) - medicine , graves' disease , thyroid , hormone , endocrinology , disease , thyroid disease , thyroid stimulating hormone
We report here a case of neonatal hyperthyroidism born to a mother, whose pregnancy was complicated by poorly controlled Graves' disease. The patient demonstrated exophthalmos and marked goiter at birth, indicating the existence of thyrotoxicosis in utero. The mother's Graves' disease was well controlled in the third trimester, resulting in a slightly lower level of free thyroxine (FT 4 ) in the umbilical cord blood serum; however, thyroid‐stimulating hormone (TSH) was undetectable. Thyroid‐stimulating hormone remained undetectable for 2 months, while FT 4 levels varied in the course. This case suggests that severe and prolonged thyrotoxicosis in utero, due to poor control of pregnancy with Graves' disease, might induce unresponsiveness of the hypothalamo‐pituitary system in the newborn.