Premium
Antineutrophil cytoplasmic antibody‐positive crescentic glomerulonephritis associated with propylthiouracil therapy
Author(s) -
Fujieda Mikiya,
Ata Michio Nag,
Akioka Yuko,
Hattori Motoshi,
Kawaguchi Hiroshi,
Ito Katsumi
Publication year - 1998
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1998.tb01930.x
Subject(s) - medicine , propylthiouracil , anti neutrophil cytoplasmic antibody , glomerulonephritis , vasculitis , pathogenesis , rapidly progressive glomerulonephritis , antibody , immunology , pathology , kidney , thyroid , disease
A teenage girl with crescentic glomerulonephritis had antineutrophil cytoplasmic antibody (ANCA) detected after she had received propylthiouracil (PTU) for hyperthyroidism without cutaneous vasculitis. ANCA was detected on admission; renal biopsy showed crescentic glomerulonephritis with focal necrotizing glomerulonephritis but no immune deposits. Administration of steroid and decreasing the dose of PTU produced a good clinical response and the ANCA disappeared. It was concluded that ANCA is closely related to the pathogenesis of crescentic glomerulonephritis and that treatment with PTU appeared to induce ANCA.