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Inhaled nitric oxide therapy via nasopharyngeal tube in an infant with end‐stage pulmonary hypertension
Author(s) -
Kakuya Fujio,
Takase Masashi,
Ishii Noriyuki,
Kajino Mayumi,
Hayashi Tokitsugi,
Miyamoto Kazutoshi,
Muraki Senichi,
Iwamoto Jun,
Okuno Akimasa
Publication year - 1998
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1998.tb01902.x
Subject(s) - medicine , sedation , hypoxemia , intubation , inhalation , anesthesia , pulmonary hypertension , nitric oxide , methemoglobin , hemoglobin
The delivery of nitric oxide (NO) via a nasopharyngeal tube is an alternative to endotracheal intubation. A male infant with end‐stage pulmonary hypertension (PH) due to a severe hypoplastic lung developed a PH crisis on day 145 and received NO inhalation via a nasopharyngeal tube. Clinical improvement was maintained for 7 days with18–22ppm NO inhalation. The patient remained in close physical contact with his parents without the use of sedation. Blood methemoglobin levels remained below 1%. The environmental NO levels were less than 0.06 ppm and NO 2 less than 0.3 ppm throughout the treatment, well within the safety margin. On day 152, the patient succumbed to hypoxemia and heart failure. The use of a nasopharyngeal NO delivery system without sedation, as an alternative to endotracheal intubation with sedation, was a practical method in treating a patient with PH while maintaining a certain quality of life for the patient and the family.