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Ionized magnesium level in whole blood of healthy Japanese children
Author(s) -
Hoshino Kenji,
Ogawa Kiyoshi,
Kitazawa Reiko,
Nakamura Yoshihiro,
Uehara Ritei
Publication year - 1998
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1998.tb01894.x
Subject(s) - magnesium , medicine , calcium metabolism , calcium , enzyme , endocrinology , whole blood , biochemistry , biology , chemistry , organic chemistry
Magnesium (Mg) catalyzes or activates more than 300 enzymes in the body, and it plays a pivotal role in the metabolism of carbohydrates, fats and proteins. Until recently Mg has only been measured as a total substance concentration; however, it is the free ionized form of magnesium (iMg 2 + ) that is physiologically active. In 1992, a novel ion selective electrode (ISE) utilizing a neutral carrier‐based membrane for assessment of iMg 2 + in whole blood, plasma or serum was designed and it was used to measure the iMg 2+ level in whole blood of 160 healthy Japanese children. There was a significant positive correlation between serum total magnesium (SMg) and iMg 2 + . Percent ionized magnesium (iMg 2 + /SMg) was 58.3 ± 4.1 % and increased with growth (age and bodyweight). The level of iMg 2 + was 1.29 ± 0.08 mg/dL (range, 1.09–1.51) {0.535 ± 0.033 mmol/L (range. 0.452–0.627)} and was constant irrespective of growth. On the other hand. SMg, serum total calcium (SCa) and ionized calcium (iCa 2+ ) decreased with growth. Thus only iMg 2 + level was constant irrespective of growth. It is suspected that the buffer action of protein binding Mg may keep the iMg 2 + level constant, because iMg 2 + plays an important part in the activation of many enzymes.