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Growth hormone stimulation tests in chronic renal failure with metabolic acidosis
Author(s) -
BIRCAN ZELÂL,
KERVANCIOǦL̈ MEHMET,
SORAN MUSTAFA,
YILDIRIM IDRIS
Publication year - 1998
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1998.tb01406.x
Subject(s) - metabolic acidosis , medicine , endocrinology , acidosis , stimulation , growth hormone , metabolic disorder , chronic renal failure , hormone
Metabolic acidosis is one of the possible causes of growth retardation in chronic renal failure (CRT 3 '). Data about the effect of metabolic acidosis on growth hormone (GH) secretion in CRF are limited. A study was earned out on eight CRF patients, hospitalized because of severe metabolic acidosis, and eight age‐matched prepubertal healthy short children. Growth hormone stimulation tests were done with L‐dopa and clonidine before or during acidosis therapy and after the correction of metabolic acidosis. The levels of GH were measured by radio‐immunoassay. The mean of the peaks of both tests were used for each patient and statistical significance was tested by Mann‐Whitney U and Wilcoxon tests. No difference was found between the GH peaks of the two groups during acidosis and after the correction of acidosis (Wilcoxon test, P > 0.05). In view of this data it was concluded that metabolic acidosis has little effect on GH stimulation tests.