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Surface marker patterns of T cells and expression of interleukin‐2 receptor in measles infection
Author(s) -
ADDAE MICHAEL MARK,
KOMADA YOSHIHIRO,
TANIGUCHI KIYOSU,
KAMIYA TOSHIYA,
OSEIKWASI MUBARAK,
AKANMORI BARTHOLOMEW DICKY,
NKRUMAH FRANCIS KWAME
Publication year - 1998
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1998.tb01394.x
Subject(s) - ionomycin , il 2 receptor , medicine , measles , measles virus , immunology , cd8 , interleukin 2 , cd3 , t cell , virology , immune system , vaccination , stimulation
The surface marker patterns of T cells of Ghanaian children during measles infection were studied and an attempt was made to demonstrate T cell activation and viability in vitro after activation in vivo by measles virus. The frequencies of CD4 + and CD8 + naive T cells in measles patients were high while their memory T cells were remarkably reduced with no sign of proliferation even at the acute phase of the illness. The reduction of memory T cells was prolonged during the convalescent phase (2 months after onset). The anti‐CD3 monoclonal antibody‐induced expression of interleukin‐2 receptor α chain (IL‐2R/CD25) was significantly suppressed; however, the addition of phorbol 12‐myristate 13‐acetate or ionomycin caused a remarkable recovery of CD25 expression. On simple culture, an appreciable proportion of T cells from measles patients died rapidly in contrast with only a few T cells from healthy controls doing so. The suppression of CD25 expression was still demonstrated during the convalescent phase of the disease. Taken together these results suggest unresponsiveness and activation‐induced cell death of T cells during severe measles infection in Ghanaian children. Furthermore the prolonged abnormalities of T cells (i.e. decreased memory T cells and inhibition of CD25 expression during the convalescent phase) might be related to post‐measles infection immunosuppressive status.