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Neonatal alloimmune thrombocytopenia associated with anti‐human platelet antigen‐3a antibody
Author(s) -
TAKADA HIDETOSHI,
NAKAMURA SHIGEYUKI,
NISHIGUCHI TOSHIHIRO,
MIYAKE KAZUYA,
HAMADA KEISUKE,
OSHIKAWA HIDETSUGU,
SHINGU TOSHIMITSU,
MORITA SHOJI,
SHIBATA YOICHI
Publication year - 1997
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1997.tb03757.x
Subject(s) - medicine , neonatal alloimmune thrombocytopenia , platelet , thrombocytopenic purpura , antibody , immunology , brother , antigen , purpura (gastropod) , platelet disorder , pediatrics , pregnancy , fetus , ecology , genetics , sociology , anthropology , biology
A sister and brother with neonatal alloimmune thrombocytopenic purpura (NAITP) caused by maternal anti‐human platelet antigen (HPA)‐3a are reported. The children had transient severe thrombocytopenia in the newborn period, and were treated with intravenous γ‐globulin and platelet concentrates from random donors. Although the sister had intracranial hemorrhage on day 2 postnatally, the development of the child has been normal and no neurological sequelae have been observed. The brother only had bloody stool when the platelet count was low, and did not have severe hemorrhagic manifestations. The diagnosis of NAITP was made by the sera from the mother, which contained anti‐HPA‐3a antibody directed against platelets of the children. The rate of recurrence might be high in this family, because the father of the patients was found to be homozygous for the HPA‐3a gene.