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Age‐related changes of serum progastrin‐releasing peptide levels during childhood
Author(s) -
ADACHI NAOTO,
AOYAGI KATSUMI,
SAITO MIHO,
MATSUDA ICHIRO,
YAMAGUCHI KEN
Publication year - 1997
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1111/j.1442-200x.1997.tb03747.x
Subject(s) - medicine , gastrin releasing peptide , cord blood , hormone , blood serum , endocrinology , physiology , neuropeptide , receptor , bombesin
Gastrin‐releasing peptide (GRP) has attracted much attention in recent years because it has become recognized as a significant tisue‐specific growth factor. To investigate the physiological significance of this peptide in growing children, the time course of serum ProGRP(31–98) level, a precursor hormone of GRP, in children was assessed. A total of 118 serum samples including cord blood was examined with informed consent by using a specific enzyme‐linked immunosorbent assay (ELISA) system to measure serum ProGRP(31–98). The serum ProGRP(31–98) level was highest in cord blood and neonatal samples, rapidly declined by 1 year of age and then gradually declined to the adult level by 5 years of age. This time‐dependent change of serum ProGRP(31–98) level suggests the importance of GRP as a physiological growth factor in fetal and neonatal tissues.